Effect of cyclic dipeptides containing histidine on pentobarbital narcosis.
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چکیده
منابع مشابه
effect of oral presentation on development of l2 learners grammar
this experimental study has been conducted to test the effect of oral presentation on the development of l2 learners grammar. but this oral presentation is not merely a deductive instruction of grammatical points, in this presentation two hypotheses of krashen (input and low filter hypotheses), stevicks viewpoints on grammar explanation and correction and widdowsons opinion on limited use of l1...
15 صفحه اولExploring the space of histidine containing dipeptides in search of novel efficient RCS sequestering agents.
The study reports a set of forty proteinogenic histidine-containing dipeptides as potential carbonyl quenchers. The peptides were chosen to cover as exhaustively as possible the accessible chemical space, and their quenching activities toward 4-hydroxy-2-nonenal (HNE) and pyridoxal were evaluated by HPLC analyses. The peptides were capped at the C-terminus as methyl esters or amides to favor th...
متن کاملPredicting the physicochemical profile of diastereoisomeric histidine-containing dipeptides by property space analysis.
OBJECTIVES This study aimed at measuring the lipophilicity and ionization constants of diastereoisomeric dipeptides, interpreting them in terms of conformational behavior, and developing statistical models to predict them. METHODS A series of 20 dipeptides of general structure NH(2)-L-X-(L or D)-His-OMe was designed and synthetized. Their experimental ionization constants (pK(1), pK(2) and pK...
متن کاملIntestinal absorption of dipeptides containing glycine, phenylalanine, proline, beta-alanine or histidine in the rat.
1 . The intestinal absorption of carnosine, glycylglycine, glycyl-D-phenylalanine, glycyl-L-phenylalanine, glycyl-L-proline and L-prolylglycine were investigated after intraluminal injection of dipeptide into anaesthetized rats. 2. With all six dipeptides, the intact substance was detected by ion-exchange chromatography in blood samples taken from the superior mesenteric vein. 3. The rate of hy...
متن کاملMuscle Histidine-Containing Dipeptides Are Elevated by Glucose Intolerance in Both Rodents and Men
OBJECTIVE Muscle carnosine and its methylated form anserine are histidine-containing dipeptides. Both dipeptides have the ability to quench reactive carbonyl species and previous studies have shown that endogenous tissue levels are decreased in chronic diseases, such as diabetes. DESIGN AND METHODS Rodent study: Skeletal muscles of rats and mice were collected from 4 different diet-interventi...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1981
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.4.377